ABP

ABP Viral Vectors in Rodents

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) describes prudent practices, procedures, and equipment to reduce risk when introducing viral vectors (e.g. lentiviral, adenoviral) into laboratory rodents at Animal Biosafety Level 2 (ABSL-2).

ABP Infectious Agents in Rodents

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) describes prudent practices, procedures, and equipment to reduce risk when inoculating infectious agents in rodents at Animal Biosafety Level 2 (ABSL-2). The practices and procedures follow those described in the CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL), 6th edition.

ABP Infectious Agents in Non-Rodents

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) provides guidance on prudent, risk-based practices, procedures, and equipment to reduce risk when inoculating infectious agents in non-rodent animal species that cannot be manipulated inside a biosafety cabinet (e.g., goats, cows, dogs, cats).

ABP Human Cells in Rodents

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) describes prudent practices, procedures, and equipment to reduce risk when implanting human cells in rodents at Animal Biosafety Level 2 (ABSL-2). Potential hazards include bloodborne pathogens (BBPs) such as HIV, Hepatitis B, Hepatitis C, and other human bloodborne pathogens. It is important to recognize that BBPs are not limited to HIV and Hepatitis viruses; other pathogens, such as syphilis, malaria, and certain arboviruses, can also pose risks.

ABP Use of Formaldehyde for Fixation of Whole Animals and Tissues

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) outlines the practices and procedures for working with formaldehyde (37% solution) and paraformaldehyde (white crystalline powder of polymerized formaldehyde) in whole animals or tissues, particularly during perfusion fixation, which poses a higher exposure risk than immersion. Formaldehyde is a carcinogen, and its use must comply with OSHA standards:

ABP Carcinogens and Other Toxic Chemicals in Rodents

1. Purpose and Scope

This Animal Biosafety Procedure (ABP) outlines prudent practices, procedures, and equipment to reduce risks when introducing carcinogens and other toxic chemical agents in laboratory rodents. Specific precautions will vary depending on the particular chemical, dose, route of administration, and metabolism of the chemical. An agent is considered carcinogenic or toxic if indicated in the Safety Data Sheet (SDS) or listed in Reference documents (Section 9).